“Can you please spell Gabbana?” Andy Sachs, the character played by Anne Hathaway, asks in the early moments of “The Devil Wears Prada.”

Twenty years later, she seems to have gotten it down.

The movie, released in 2006, starred Ms. Hathaway as the blunder-prone assistant to Miranda Priestly, a fashion magazine editor played by Meryl Streep who has a gaze withering enough to penetrate the darkest of sunglasses. A new sequel considers how their dynamic — and the media landscape they occupy — has shifted after two decades.

At the movie’s premiere in Manhattan on Monday night, Ms. Hathaway and Ms. Streep posed with their co-stars Stanley Tucci and Emily Blunt on a red carpet outside Lincoln Center. There was screaming followed by even more screaming from fans who had been waiting outside for hours in hopes of an autograph from Ms. Streep.

“She’s a boss,” said Brielle Fertucci, 15, who was lined up outside to cheer even though she had not yet been born when the first movie was released.