With a roster of artists that includes Marina Abramovi?, Terence Koh, and Kehinde Wiley, Manhattan gallerist Sean Kelly is no stranger to boundary-pushing work. So when the time came to expand and relocate his operation, based for more than a decade on 29th Street in Chelsea, it made sense that he would look beyond the neighborhood’s established art-world borders.

Opened in October—and thankfully spared by Hurricane Sandy—the new Sean Kelly Gallery sits just north of its old spot, on a quiet corner of Tenth Avenue and 36th Street in the up-and-coming Hudson Yards area. To transform the 22,000-square-foot venue, which spans two floors of a 1914 building, Kelly tapped architect Toshiko Mori, a longtime friend who also recently completed Kelly’s family house in New York’s Hudson Valley.

Exhibition spaces, alternately intimate and grand, have been thoughtfully configured within the cavernous interiors, providing a pristine backdrop for the new gallery’s inaugural show, a display of sculptures by Antony Gormley on view through December 22.

Complementing those rooms are a black-box theater for performances and a warren of sleek offices, including a pair of glass-enclosed directors’ chambers and a library outfitted with a one-of-a-kind light installation by glass artist Jeff Zimmerman. The move, which more than tripled the gallery’s size, has hardly deterred traffic—as the packed opening-night party proved, art aficionados are happy to embrace a road less traveled.

Sean Kelly Gallery, 475 Tenth Ave., New York, NY; skny.com