Luca Guadagnino has added creative director to his list of jobs.

As a filmmaker, his credits include “Challengers,” the Oscar-nominated movie “Call Me by Your Name” and the upcoming “Queer,” an adaptation of William S. Burroughs’s semi-autobiographical novella starring Daniel Craig, which recently premiered at the Venice Film Festival. He is also the founder of Studio Luca Guadagnino, an award-winning interiors firm in Milan that has designed several homes, boutiques and, most recently, the Palazzo Talia hotel in Rome.

Now, Mr. Guadagnino has marshaled the staging and curation of Homo Faber, a monthlong, biennial craftsmanship exhibition that opened on Sunday at the Giorgio Cini Foundation, a cultural center on San Giorgio Maggiore island in Venice. Homo Faber, which means “man the maker” in Latin, is put on by the Michelangelo Foundation for Creativity and Craftsmanship, a Geneva-based non-profit established by Italian author Franco Cologni and luxury industry billionaire Johann Rupert, chairman of Richemont, which owns the brands Cartier, Van Cleef & Arpels and Alaïa. Mr. Guadagnino partnered with his design studio project manager, Nicolò Rosmarini, to conceive this third edition as a “holistic experience — like a narrative,” he said.

To achieve this, Mr. Guadagnino and Mr. Rosmarini created an immersive journey throughout the island’s 16th-century Palladio-designed monastery and assorted buildings that carries visitors through 10 multisensory set pieces, each dedicated to an aspect of the human experience like Childhood, Courtship and Dreams. They designed everything (“the lighting system, the uniforms, the tote bag, the tables, the cover of the cable on the floor,” Mr. Guadagnino said) then filled the rooms with 800 objects by 400 artisans from 70 countries.